NEPHROTIC SYNDROME WITH INCREASING EDEMA

#69Urology & Nephrology

NEPHROTIC SYNDROME WITH INCREASING EDEMA

Patient HZB
Patient H., female, 30 years old, married, with a 1.5-year-old child, came with complaints of abdominal swelling and edema of both legs from the ankles down for 6 months. Diagnosed with idiopathic nephrotic syndrome HSA, JB. Skin on the legs is glossy, edema significant, making wearing shoes difficult. Additionally, there's ascites.

At the start of therapy, she was taking prednisolone 15 mg daily, T. Lasix 20 mg, T. Slow K. Four months before these events, she had herpes zoster complicating the right chest, leaving a scar after healing. However, the prednisolone dose cannot be reduced due to worsening symptoms and proteinuria.

Protein in urine was three plus (+++), serum albumin 16 mg/dl. These levels are typical for most of her tests.

She underwent a month of resonance therapy daily.

Result: Leg edema noticeably decreased, returning the legs to normal size. Protein in urine reduced to ++, but serum albumin remained between 13-16 mg/dl. The supervising therapist reduced the daily prednisolone dose to 10 mg. Serum protein increased to +++, but serum albumin stayed the same. Waist circumference reduced by 3 cm. Body weight decreased from 45 to 40 kg, possibly due to tissue fluid loss (reduced edema).

An interesting observation was that the legs returned to normal size after 20 days of treatment, allowing for a two-thirds reduction in prednisolone (to 5 mg daily), discontinuation of Lasix and Slow K. After 30 days of therapy, she was advised to come weekly. The clinical picture remained unchanged, with no further improvement in biochemical tests. Therefore, treatment was stopped. A longer course was not feasible as the patient came from far away and had to take a month off work.

Side Effect: After the fifth session, pinpoint hemorrhages and knee pain were noted on one leg. These symptoms resolved within a week of continuing treatment.

Comments: Notably, the ZB emitter clearly affected the reduction of excess fluid in the leg vessels, while serum protein levels remained unchanged. However, the prednisolone dose was reduced by two-thirds compared to the initial dose. In this case, there was significant symptomatic improvement.