An 11-year-old patient came with complaints of severe general weakness, constant subfebrile temperature, and joint pain. Examination revealed LE cells, positive C-reactive protein, leukocytes up to 15 in the urine field of view, protein 0.0033%, and an ESR of 30 mm/h. She has been ill for 3 years. Despite treatment, her ESR remained consistently high. On examination, the patient was underweight with a poor appetite. Joints were not deformed. She consistently had a subfebrile temperature of 37.2-37.3°C. Treatment was carried out using an antiviral emitter RV, procedures to restore gut flora (GI) and immunity (KB). After local emitters, general action emitters RC, GI, KB were applied. As a result of the treatment, after 3 weeks, the ESR decreased to 20 mm/h. The temperature rose periodically. The patient's appetite improved, and she started gaining weight.